Remnant Cholesterol
نویسنده
چکیده
In this issue the Journal, Varbo et al. (1) demonstrate that irrespective of the fasting state, the cholesterol transported by remnant lipoproteins is a robust predictor of coronary artery disease (CAD) risk. Their findings provide clarification to the debate regarding triglyceride-rich lipoproteins and atherosclerosis (2). Overall, a consensus is emerging on the basis of clinical and population data and genetic studies that fasting and nonfasting plasma triglycerides are predictive of both CAD and stroke risk, although the relationship is attenuated after correction for associated variables, including high-density lipoprotein cholesterol (HDL-C). However, triglycerides per se are not considered to be direct culprits in the atherogenic process, hence the appropriate focus in this report on the cholesterol component of triglyceride-rich lipoproteins.
منابع مشابه
Remnant cholesterol as a cause of ischemic heart disease: evidence, definition, measurement, atherogenicity, high risk patients, and present and future treatment.
This review focuses on remnant cholesterol as a causal risk factor for ischemic heart disease (IHD), on its definition, measurement, atherogenicity, and levels in high risk patient groups; in addition, present and future pharmacological approaches to lowering remnant cholesterol levels are considered. Observational studies show association between elevated levels of remnant cholesterol and incr...
متن کاملExtreme nonfasting remnant cholesterol vs extreme LDL cholesterol as contributors to cardiovascular disease and all-cause mortality in 90000 individuals from the general population.
BACKGROUND Increased nonfasting remnant cholesterol, like increased LDL cholesterol, is causally associated with increased risk for ischemic heart disease (IHD). We tested the hypothesis that extreme concentrations of nonfasting remnant and LDL cholesterol are equal contributors to the risk of IHD, myocardial infarction (MI), and all-cause mortality. METHODS We compared stepwise increasing co...
متن کاملPremature myocardial infarction is strongly associated with increased levels of remnant cholesterol.
BACKGROUND Remnant cholesterol has been defined as the cholesterol present in triglyceride-rich remnant lipoproteins. Elevated levels of remnant cholesterol have been associated with increased cardiovascular risk. Acute myocardial infarction (AMI) in very young individuals (≤40 years) represents a rare disease with a typical risk factor profile and a lipid phenotype that is characterized by a p...
متن کاملRelationships between cholesterol homoeostasis and triacylglycerol-rich lipoprotein remnant metabolism in the metabolic syndrome.
The dysmetabolic syndrome of insulin resistance and visceral obesity is characterized by elevated plasma concentration of triacylglycerol-rich lipoprotein (TRL) remnants that may be related to increased cardiovascular risk. Perturbed hepato-intestinal cholesterol metabolism may play a contributory role in this abnormality. We therefore investigated the association between plasma markers of chol...
متن کاملElevated remnant cholesterol causes both low-grade inflammation and ischemic heart disease, whereas elevated low-density lipoprotein cholesterol causes ischemic heart disease without inflammation.
BACKGROUND Elevated nonfasting remnant cholesterol and low-density lipoprotein (LDL) cholesterol are causally associated with ischemic heart disease (IHD), but whether elevated nonfasting remnant cholesterol and LDL cholesterol both cause low-grade inflammation is currently unknown. METHODS AND RESULTS We studied 60 608 individuals from the Copenhagen General Population Study, the Copenhagen ...
متن کاملEffect of atorvastatin on chylomicron remnant metabolism in visceral obesity: a study employing a new stable isotope breath test.
Elevated plasma concentration of chylomicron remnants may be causally related to atherosclerosis in obesity. We examined the effect of atorvastatin on chylomicron remnant metabolism in 25 obese men with dyslipidaemia. A remnant-like emulsion labeled with cholesteryl [(13)C]oleate was injected intravenously into patients; the fractional catabolic rate (FCR) of the remnant-like emulsion was deter...
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